Bolton will touch down in the Turkish capital, Ankara, where he will be joined by US Joint Chief of Staff General Joseph Dunford, having stated that the US pullout is conditional on defeating the Islamic State of Iraq and the Levant (ISIL, also known as ISIS), as well as Turkish assurances on the security of the US's Kurdish militia allies.
President Donald Trump's December 19 announcement of the withdrawal of 2,000 troops from Syria has heightened expectations that Turkey could launch a military operation targeting the People's Protection Units (YPG), which has spearheaded the US-allied Syrian Democratic Forces (SDF) in the fight against ISIL.
"We don't think the Turks ought to undertake military action that's not fully coordinated with and agreed to by the United States," Bolton told reporters in Jerusalem on Sunday.
He added Turkey must "meet the president's requirement that the Syrian opposition forces that have fought with us are not endangered."
The US alliance with the YPG, which it has helped arm and train, has been one of the main stumbling blocks in relations with Ankara because of YPG's ties to the Kurdistan Workers' Party (PKK). Since 1984 the PKK has waged a war against Turkey that has led to more than 40,000 deaths.
Ankara regards both the Kurdish groups as "terrorist" organisations.