How Our Brains Turn Into Smarter Disease Fighters

Health 19:17 01.02.2023
Combating Alzheimer’s and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists at the University of California, Irvine and the University of Pennsylvania have found a way to safely thwart the brain’s resistance to them, vaulting a key hurdle in the quest.
Their discovery about brain cells called microglia heralds myriad possibilities for treating and even preventing neurodegenerative disorders. The team’s paper appears in the Journal of Experimental Medicine.
Link to study:
When microglia are healthy, they serve as the central nervous system’s resident front-line disease warriors. “However, there is overwhelming evidence that they can become dysfunctional in many neurological conditions,” said Mathew Blurton-Jones, UCI professor of neurobiology & behavior and study co-lead author. “Until recently, scientists have mainly been looking at the mechanisms that drive microglial dysfunction and trying to find drugs to change their activity. But with this study, we’ve found a way to potentially harness microglia themselves to treat those diseases.”
Frederick “Chris” Bennett, assistant professor of psychiatry at Penn and co-lead author, added: “There is an obstacle because once our own microglia develop in the location where they are supposed to be in our brains, they don’t give up that space. They block the ability to deliver new cells that would take their place. If you want to insert donor microglia, you have to deplete the host microglia to open up room.”
Bennett and his laboratory partnered with Blurton-Jones and his lab on the project.
Microglia depend on signaling by a protein on their surface called CSF1R for their survival. The FDA-approved cancer drug pexidartinib has been found to block that signaling, killing them. This process would seem to offer a way to clear space in the brain to insert healthy donor microglia. However, there is a dilemma – unless the pexidartinib is stopped before the donor microglia are added, it will eliminate them, too. But once the drug is terminated, the host microglia regenerate too fast to effectively put in the donor cells.
This quandary has challenged efforts to treat people with certain rare and severe neurologic conditions. One is Krabbe disease, in which the body’s cells can’t digest certain fats that are highly abundant in the brain. Currently, clinicians use bone marrow transplantation and chemotherapy to try to introduce new immune cells similar to microglia into the brain. But this approach can be toxic and must be carried out before Krabbe symptoms manifest.
“Our team believed that if we could overcome the brain’s resistance to accepting new microglia, we could successfully transplant them into patients using a safer, more effective process in order to target a great number of diseases,” said co-first author Sonia Lombroso, a Penn Ph.D. student and member of the Bennett Lab. “We decided to investigate whether we could make the donor microglia resistant to the drug that eliminates their host counterparts.”
The researchers used CRISPR gene-editing technology to create one amino acid mutation, known as G795A, which they introduced into donor microglia produced from human stem cells or a mouse microglial cell line. Then they injected the donor microglia into humanized rodent models while administering pexidartinib, with exciting results.
“We discovered that this one small mutation caused the donor microglia to resist the drug and thrive, while the host microglia continued to die off,” said co-first author Jean Paul Chadarevian, a UCI Ph.D. student who is a member of the Blurton-Jones Lab. “This finding could lead to many options for developing new microglial-based treatments. Pexidartinib is already approved for clinical use and appears to be relatively well tolerated by patients.”
Approaches could range from fighting disease by replacing dysfunctional microglia with healthy ones to designing microglia that can recognize imminent threats and strike against them with therapeutic proteins before they cause harm.
The UCI-Penn team believes treatments based on this kind of microglial method could be developed within a decade. Their next investigations include studying in rodent models how to use the approach to attack the brain plaques associated with Alzheimer’s and to counter Krabbe and other similar diseases.
Support for the project was provided by the National Institutes of Health, National Science Foundation, The Paul Allen Frontiers Group, Klingenstein-Simons Fellowship Award in Neuroscience and the Susan Scott Foundation.
Euronews broadcast interview with President Ilham Aliyev - VIDEO

News line

At least 25 Palestinians killed in strike near Red Cross office in Gaza
13:25 22.06.2024
German Economy Minister Habeck visits China
German Economy Minister Habeck visits China
13:00 22.06.2024
President: Azerbaijan is attractive for investors in both fossil fuels and renewables
12:46 22.06.2024
Taiwan detects 41 Chinese aircraft around island
12:26 22.06.2024
US Olympic gold medalist Gil Roberts gets 8-year doping suspension
US Olympic gold medalist Gil Roberts gets 8-year doping suspension
12:00 22.06.2024
Baku Energy Forum focuses on AI, economic growth, and clean energy transition - COVERAGE
11:39 22.06.2024
Ambassador: Pakistan ready to join North-South International Transport Corridor
11:25 22.06.2024
Euronews broadcast interview with President Ilham Aliyev - VIDEO
11:00 22.06.2024
Azerbaijani Army positions in Kalbajar subjected to fire
10:42 22.06.2024
Putin vows to strengthen Russia's nuclear triad as global deterrent
10:00 22.06.2024
EU set to sign security pact with Ukraine in June
09:44 22.06.2024
Apple reportedly delays AI features rollout in EU
Apple reportedly delays AI features rollout in EU
09:24 22.06.2024
Iran: Hezbollah can defend itself, Lebanon against Israel
09:00 22.06.2024
Austria defeats Poland 3-1 in Euro 2024 group stage
23:00 21.06.2024
Israel's Health Ministry warns of West Nile fever outbreak
Israel's Health Ministry warns of West Nile fever outbreak
22:19 21.06.2024
Germany arrests Russian, Ukrainian, and Armenian nationals on suspicion of espionage
21:10 21.06.2024
Azerbaijan's Foreign Minister Bayramov bids farewell to Kyrgyz envoy
20:15 21.06.2024
Russia open to talks with US if Ukraine issue included
19:52 21.06.2024
EU confirms starting talks with Ukraine, Moldova next week
19:24 21.06.2024
Number of landmine victims in Azerbaijan exceeds 360, Baku says
Number of landmine victims in Azerbaijan exceeds 360, Baku says
19:00 21.06.2024
Death toll in Turkish wildfire rises to 8
Death toll in Turkish wildfire rises to 8
18:43 21.06.2024
Israel MFA summons Armenian ambassador amid Palestine recognition
18:25 21.06.2024
Azerbaijan prohibits cousin marriage
18:05 21.06.2024
EU mulls suspension of high-level visits to Georgia
17:49 21.06.2024
London to host 2nd COP29-IEA High-Level Dialogue
17:16 21.06.2024
Yerevan police confiscates car serving seperatist Samvel Shahramanyan - VIDEO
16:59 21.06.2024
Miraculous Indonesia and Associated Policies for Pakistan - ANALYSIS
16:00 21.06.2024
Azerbaijan determines punishments for forcing early marriage
15:42 21.06.2024
US Embassy expressed its condolences to family of deceased ANAMA employee
15:25 21.06.2024
Azerbaijan handed over remains of 2 Armenian soldiers to other side
15:00 21.06.2024
Football legend Roberto Baggio Injured in Armed Robbery
Football legend Roberto Baggio Injured in Armed Robbery
14:22 21.06.2024
President Ilham Aliyev and First Lady Mehriban Aliyeva attend opening of new building of Institute of Botany in Baku
14:11 21.06.2024
Lavrov: Putin's initiative marks Russia's fourth proposal for Ukraine settlement
12:49 21.06.2024
Azerbaijan's strategic currency reserves near $70B
Azerbaijan's strategic currency reserves near $70B
12:09 21.06.2024
Armenia recognizes the State of Palestine
Armenia recognizes the State of Palestine
11:55 21.06.2024
BREAKING NEWS: Ammunition explosion in Azerbaijan's Jabrayil kills ANAMA employee
11:42 21.06.2024
Election Headquarters of Iranian Presidential Candidate Set on Fire - VIDEO
Election Headquarters of Iranian Presidential Candidate Set on Fire - VIDEO
11:30 21.06.2024
Iran MFA Summons Italian Ambassador
11:22 21.06.2024
Azerbaijani Parliament Adds Early Elections Proposal to Agenda
11:02 21.06.2024
What is Hezbollah’s message behind their spy drone video?
10:43 21.06.2024