The bus smashed into a roadside barrier on a national highway and caught fire, according to Taiwan's Central News Agency (CNA).
It had been bringing the group of Chinese tourists to Taoyuan Airport to catch a flight back to Dalian.
Officials said there were 24 tourists on board plus a local guide and driver.
The cause of the crash was not immediately known.
The total number of dead and injured is still being compiled, Taoyuan fire department official Zeng Hao told news agency AP by phone.
